Therapeutic efficacy testing of Rombendazol 10% (Romvac) and Fasinex (Novartis) in natural infestation with Fasciola hepatica at sheep from Bilbor, Harghita County

Authors: M. Tifrea1, I. Oprescu2, D. Indre2, Mirela Imre2, Gh. Darabus2

Affiliation: 1 CSVA Bilbor, Harghita;
                       2 USAMVB Timisoara, Faculty of Veterinary de Medicine

The study was carried out between January -February 2008, on 30 sheep Tigaie and Turcana breeds from Bilbor, Harghita County. Animals were distributed randomly into three groups (n=10): group A1 (treated with albendazole), group B1 (treated with triclabendazole) and control group (M) – the dosage used was the one recommended by the producer. Coproscopical examination was made on days 0 and 14 using the methods recommended by WAAVP and the efficacy was evaluated using Presidente relation. Investigations revealed an efficacy value of 98.35% for Fasinex and 71.55% for Rombendazol 10%.

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Guidelines for euthanasia of laboratory animals used in biomedical research

Authors: Adina Baias1, Romeo T. Cristina1, Viorica Chiurciu2

Affiliation: 1 USAMVB Timisoara, Facultatea de Medicina Veterinara                                                                                2 Romvac Company SA, Bucuresti

Laboratory animals are used in several fields of science research, especially in biology, medicine and veterinary
medicine. The majority of laboratory animals used in research are experimental models that replace the human body in study regarding pharmacological or biological safety products, studies conducted for a better understanding of onchologic processes, toxicology, genetic studies or even new surgical techniques. Experimental protocols include a stage in which animals are euthanasized in order to remove organs and tissues, or for no unnecessary pain and suffering of animals (humane endpoints) or to mark the end of research. The result of euthanasia techniques is a rapid loss of consciousness followed by cardiac arrest, respiratory arrest and disruption of brain activity. Nowadays, the accepted euthanasia techniques can use chemicals (inhalant agents like: carbon dioxide, nitrogen or argon, overdoses of injectable anesthetics) or physical methods (decapitation, cervical spine dislocation, stunning, gunshot, pitching).

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Small guide to using drugs in laboratory animals, birds and reptiles

Authors: Viorica Chiurciu1, Adina Faur (Baias)2, Eugenia Dumitrescu2, Romeo T. Cristina2

Affiliation: 1 Romvac Company Bucuresti,                                                                                                                      2 USAMVB Timisoara, Facultatea de Medicina Veterinara

Laboratory animals (namely, mouse, rat, hamster, guinea pig, rabbit), chinchillas, birds and reptilian medicine is a relatively new specialty of veterinary medicine, being until recently in the “early” stages, therefore at least in the last decade, some studies on these types of animals appeared in the literature and consequently, therapy issues of various disease states in these animals. Besides the fact that laboratory animals and reptiles are used in biomedical research, we would say, already routinely not to neglect is the growing number of holders of such “pet animals”. In search of appropriate dosages to these species, scientists have tried to extrapolate doses from dog and cats, based on experimental studies and then published. Based on “accumulation” of therapists in the recent years, only few drugs have been approved yet (especially for rodents), most of them having still the status application beside instructions (off-label application). Already known increased susceptibility of mice and rabbits to the toxicity of antimicrobials is particularly important due to intestinal flora, dis microbism due to narrow spectrum antibiotics often leading to the increasing of gram-negative and gram positive anaerobic, organisms which will induce in these species toxicity and death. In conclusion, dosages presented are the result of some clinical studies that could be yet considered as “empirical” and “extrapolated from other species” and which are perfectible every day by the information accumulation following the administrations. In this respect an “up to date” self-improvement of vet specialists who have interests in this field is required.

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New veterinary medicinal products authorised by centralised procedure

Author: Simona Sturzu                                                                                                                 Affiliation: Institutul pentru Controlul Produselor Biologice si Produs medicinalelor de Uz Veterinar

Veterinary medicinal products that are subject to authorization via the centralized procedure according to Regulation (EC) no. 726/2004 are included in the Community register of veterinary medicines, that is published on the European Commission website and product information of them are published on the website of the European Medicines Agency. Each competent authority involved in the linguistic review process of product information annexed to the Marketing Authorization for medicinal products authorized centrally (SPC, leaflet, information about the marketing authorization holder, product labeling conditions), approve the version in the language mother of each Member State. In the second half of 2011 have received marketing authorization via the centralized procedure a total of four veterinary medicinal products, presented above.

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Prescriptions writing in veterinary medicine

Author: Romeo Teodor Cristina                                                                                                   Affiliation: USAMVB Timisoara, Facultatea de Medicina Veterinara

Labeling, dispensing and prescribing plays an important role in current veterinary practitioner activity, movement of the veterinary medicines being governed by the Romanian law. Veterinary norm concerning the conditions of organization and functioning of veterinary pharmaceutical units and units for sale pets approved by the Order of the National Sanitary Veterinary and Food Safety no. 16 of 27 February 2008 published in the Official Monitory, Part I, nr.176 of March 7, 2008, as amended and supplemented presents the main duties and responsibilities of the veterinarian. A remembrance of veterinary medicines prescription has been requested repeatedly by many practitioners in the field and, therefore we consider, opportune re presenting the main elements in this topic, due also to the inclusion in national SNEC/2012 subject courses organized by the College and the Association of Veterinarians from Romania.

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