The efficacy of fenbendazole on horse strongyle infestation from Bazosul nou, Timis County

Authors: Morariu S.1, Dărăbus Gh.1, Oprescu I.1, N Mederle1, Ilie M.1, Milutin C.1, F. Morariu2,                               Stepanescu D.3

Affiliations: 1) USAMVB, Facultatea de Medicinã Veterinara Timisoara,                                                                             2) USAMVB, Facultatea de Zootehnie si Biotehnologii,                                                                                    3) Directia Sanitarã Veterinarã si pentru Siguranta Alimentelor Caras-Severin

In the last few years horse strongyles became very important because they are harmful and prejudicial for horses and horse owners. The large number of strongyle species and the possibility of apparition of benzimidazole compounds resistance phenomenon were on the basis of this study. After administration of 10% fenbendazole (Panacur) to randomic selected horses from Bazosul Nou, the efficacy of the anthelmintic by classical method FECRT and supplementary, by Borgsteede and Presidente relations, was calculated. The anthelmintic efficacy was over 99% by the mean of all three methods. The feces examination from treated horses revealed the presence of 19 species of strongyles.

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Anthelmintic resistance

Authors: M. Cernea, Anca Mãrculescu, Veturia Ileana Nueleanu                                                   Affiliation: USAMVB Cluj-Napoca, Facultatea de Medicină Veterinară

A thoroughgoing study on resistance was achieved for the first time in insecticides, later on finding that, this can be extended also in anthelmintic substances. The resistance to anthelmintics evolved gradually from a simple medical curiosity, to an important economic problem. Many factors contribute to the appearance of resistance to anthelmintic substances. After epidemiological studies on various helmintic populations, it was concluded that there are four essential and distinguish factors that induce the appearance of parasitic resistance: operational factors, genetic factors, biological and ecological factors. In the last two decades there were conceived many tests to give emphasis to the phenomenon of resistance, but very few were accepted and validated at an international level. The motivation for this phenomenon consist in the fact that every of this methods have a certain sensibility, feasibility and profitableness. All these tests have positive aspects, and few negative aspects, that make them hard to be utilized (apparatus and high costs) or there are not enough sensible, so the obtained results are difficult to be interpreted. The use of molecular technique for the diagnosis of resistance to anthelmintics does not represent a viable option in the present, because the data about the intimate molecular mechanisms of resistance to anthelmintics are very few and there are not confirmed by the clinical reality.

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Resistance to antibiotics

Authors: Anca Mãrculescu, M. Cernea, Veturia Nueleanu, N.A. Oros, R. Chereji                                 Affiliation:  USAMVB Cluj-Napoca, Faculty of Veterinary Medicine

The antibiotics represent the most important therapeutic arsenal in the fight against pathogen microorganisms. Even in the beginning of their use, there was registered bacterial resistance, phenomenon that became an alarming subject in the last decades. There are some types of resistance to antibiotics that are influenced by many factors. The resistance term can be used as microbiological resistance and clinical resistance. The resistance to antibiotics can be a natural phenomenon or a gained one. The mechanisms of gaining resistance in bacteria are genetic or biochemical. Because of the fact that this is an increasing phenomena, data about antibiotic resistance is a permanent necessity in any part of the world.

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The impact of anesthesia upon the main functions of the animal organism

Authors: Năstasă V., Mariana Grecu                                                                                                   Affiliation: USAMVB Iasi, Facultatea de Medicină Veterinară

The general anesthetics produce the reversible loss of consciousness and sensitivity and influence the vital functions of the organism. More than a century ago, the anesthetic was considered to be a poison which intoxicates the nervous system. Recently, it has been proved that the anesthetic substance invades all tissues. Despite these drawbacks, they are widely used in the experimental researches “in vivo”, but their use may considerably change the result of the physiological or pharmacological effects of these substances; the pharmacological details are few. The aim of this communication is to provide information referring to the interactions between general anesthetics and other pharmacological agents, limiting at the substances currently used in the experimental research.

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The changes of pharmacokinetic behavior of the medical substances as a consequence of the „in vivo” interaction with general anesthetics

Authors: Năstasă V., Maria-Magdalena Nechifor                                                                                   Affiliation: USAMVB Iasi, Faculty of Veterinary Medicine

General anesthetics are substances which produce a reversible state of unconsciousness and insensibility. Inaddition to these principal effects, anesthetics modify almost always, the other functions of the organism. The concentration of the pharmacological agent at its receptor sites and at the target organs will depend on its absorption, distribution, biotransformation and its elimination. Frequently, anesthesia considerably affects these factors, with implications on the pharmacokinetic dynamics of some pharmacological agents. The interaction phenomenon between the general anesthetic substances and other drugs is emphasized.

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Treatments in veterinary homeopathy

Author: Romeo T. Cristina                                                                                                           Affiliation: USAMVB Timisoara, Faculty of Veterinary Medicine. 

The paper is a small guide about: what is to know, being a vet, related to homeopathic therapy institution(anamnesys and clinical examination, what are the polichrests), antagonisms and synergisms, data about some homeopathic conditionings as well the doses and way of administration choosing.

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Homeopathy in veterinary medicine: general principles

Author: Romeo T. Cristina                                                                                                                     Affiliation: USAMVB Timisoara, Faculty of Veterinary Medicine

Homeopathy therapeutic means are more significantly considered as an animals treatment alternative. This because homeopathy has in its view not only the fact that is harmless for animals, but also the important aspect of lack presence of residues in animal origin products. The paper makes a short presentation of the advantages and disadvantages of this therapeutic alternative and also propose a short description of the three Hahnemian principles: of similitude, of dilutions and of individualization, with them specific aspects (decimal and centesimal dilutions, influence of constitution and temperament, the organic and functional signs analysis).

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New alternatives in veterinary anthelminthic therapy

Author: Romeo T. Cristina                                                                                                             Affiliation: USAMVB Timisoara, Faculty of Veterinary Medicine.

Present paper proposes the presentation of antiparasitic boluses, veterinary use specific conditionings with importance in gastro intestinal helminth population control, as a modern alternative to the classic antihelmintic therapy. The active substances are released consecutive to: diffusion, osmotic procesess, to progressive erosion, or through electronic programmed devices. Anthelmintic boluses are classified upon the releasing system in: a) anthelmintic sustained release systems: for albendazole (Proftril bolus), morantel tartrate (Paratect flex and bolus) ivermectines (Enzec and Alzet, Ivomec SR Bolus), levamisole (Chronominthic bolus), oxfendazol (Synanthic multidose bolus) fenbendazole (Panacur Bolus). b) anthelmintic programmed periodic release systems: Intra Ruminal Pulse Release Electronic Device (I.R.P.R.E.D) and Repidose (Autoworm, Oxfendazole Pulsed Release Bolus).

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