Drug’s analithycal investigation

Authors: Romeo T. Cristina1, Tiță D2, Eugenia Dumitrescu1, Tiță B2

Affiliation: 1 Facultatea de Medicină Veterinară Timișoara                                                                                               2 Universitatea de Medicină și Farmacie Victor Babeș Timișoara, Facultatea de Farmacie

Chemical analysis is the main method of drugs investigation. It is currently used in all scientific fields that have a greater or lesser connection with the chemistry. In a simple way we can say that the chemical analysis consists into the characterization of the analyzed system. Characterization means the obtaining and processing of all linked information that allowing the substances or components identifying of the system analysis – so called analytical information. Analytical information is obtained through the complex investigation (analysis) of the studied substance or of the analyzed system (the analytical system). This investigation is done through the monitoring and measurement of certain properties (P) depending on the concentration (C) or volume (V). Instrumental methods can be used to determine other substances characteristics as: determination of some analytical constants, structure determination, the reaction mechanisms’ elucidation, etc. Practice has shown that the best results are obtained for an analytical method by coupling the chemical techniques with the instrumental ones. In this report are presented the main features, and analytical methods used in the drugs testing.

full text (in Romanian)

About ATC / DDD drug clasiffication system

Authors: Diana Iacob (Obistioiu)1, Maria Andresescu2, Romeo T. Cristina1

Affiliation: 1 USAMVB Timișoara, Facultatea de Medicina Veterinara                                                                               2 ANSVSA Bucuresti

The field of drug utilization research has attracted increasing interest since its infancy in the 1960s. At a symposium in Oslo in 1969 entitled The Consumption of Drugs, it was agreed that an internationally accepted classification system for drug consumption studies was needed. At the same symposium the Drug Utilization Research Group (DURG) was established and tasked with the development of internationally applicable methods for drug utilization research. By modifying and extending the European Pharmaceutical Market Research Association (EPhMRA) classification system, Norwegian researchers developed a system known as the Anatomical Therapeutic Chemical (ATC) classification. In order to measure drug use, it is important to have both a classification system and a unit of measurement. To deal with the objections against traditional units of measurement, a technical unit of measurement called the Defined Daily Dose (DDD) to be used in drug utilisation studies was developed. The purpose of the ATC/DDD system is to serve as a tool for drug utilization research in order to improve quality of drug use. One component of this is the presentation and comparison of drug consumption statistics at international and other levels. The classification of a substance in the ATC/DDD system is not a recommendation for use, nor does it imply any judgements about efficacy or relative efficacy of drugs and groups of drugs. The Anatomical Therapeutic Chemical classification system for veterinary medicinal products, ATCvet, has been developed by the Nordic Council on Medicines (NLN) in collaboration with the NLN’s
ATCvet working group, consisting of experts from the Nordic countries. The ATCvet system for the classification of veterinary medicines is based on the same overall principles as the ATC system for substances used in human medicine. In most cases an ATC code exists which can be used to classify a product in the ATCvet system. The ATCvet code is then created by placing the letter Q in front of the ATC code. In some cases, however, specific ATCvet codes are created, e.g. antibacterials for intramammary use (QJ51) and Immunologicals (QI).

full text (in Romanian)