Effectiveness testing of some vegetal extracts comparing with classical anthelmintics

Authors: Ilie M.S.1, Dărabus Gh.1, Oprescu I1, Morariu S1, Narcisa Mederle1, Alina lie1, Imre K1, F. Morariu2

Affiliation: 1 Facultatea de Medicină Veterinară Timisoara,                                                                                              2 Facultatea de Zootehnie si Biotehnologii Timisoara

We have tested the efficacy of some vegetal extracts (Parazitol – Medica Laboratories, a natural product with an anthelmintic effect and a Cucurbita sp. oil extract) compared to the classic anthelmintics (Rombendazol – Romvac and Dehelman – KRKA Slovenia) at domestic poultry, whose parasitical status had been previously established through animal killing and necropsies. Parazitol and the pumpkin oil have had a lower efficacy than the levamisole and albendazole upon the species Ascaridia galli. Heterakis gallinarum was not affected by the pumpkin oil. Parazitol have a moderate efficacy (36%), while levamisole and albendazole were very efficient (100%). The treatments with albendazole upon the cestods belonging to the genus Raillietina have had a 100% efficacy. In cestods, Parazitol had a better efficacy (57%) than the pumpkin oil (14%).

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Therapeutic efficacy testing of Rombendazol 10% (Romvac) and Fasinex (Novartis) in natural infestation with Fasciola hepatica at sheep from Bilbor, Harghita County

Authors: M. Tifrea1, I. Oprescu2, D. Indre2, Mirela Imre2, Gh. Darabus2

Affiliation: 1 CSVA Bilbor, Harghita;
                       2 USAMVB Timisoara, Faculty of Veterinary de Medicine

The study was carried out between January -February 2008, on 30 sheep Tigaie and Turcana breeds from Bilbor, Harghita County. Animals were distributed randomly into three groups (n=10): group A1 (treated with albendazole), group B1 (treated with triclabendazole) and control group (M) – the dosage used was the one recommended by the producer. Coproscopical examination was made on days 0 and 14 using the methods recommended by WAAVP and the efficacy was evaluated using Presidente relation. Investigations revealed an efficacy value of 98.35% for Fasinex and 71.55% for Rombendazol 10%.

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Comparative activity of some veterinary pharmaceutical products in swine dysentery

Authors: Romeo T. Cristina1, Roberto Villa2, Olimpia-Ines Lupu (Paută)1, Alexandru Doma1

Affiliation: 1 USAMVB Timisoara, Facultatea de Medicina Veterinara                                                                                2 Universita di Milano, Facolta di Medicina Veterinaria

One of the diseases that cause great damage in the pig breeding farms, Brachyspyra swine dysentery has a special importance because involve great losses both by growth failure and high mortality and significant costs to the prevention and control. The study was conducted in a swine farm in Timis County, where the disease was originally identified in autumn of year 2009. Cumulative adverse conditions have affected the rate of morbidity and mortality. The most common clinical developments in the unit were usually acute and subacute. Research included: a comparative study of the effectiveness of tiamulin fumarate, hydrogenated and dimetridazole powder in sick acute and subacute forms in piglets, at the weaning period; the comparative study of efficiency in therapy of soluble tiamulin (the tiamulin fumarate-hydrogenated) and of the injection of piglets effective and the study of growth indicators: average daily gain.
Experiment I
Group I consisted in 15 piglets with an average weight per lot of 7.60 kg/head (batch weight: 114kg) received p.o. dimetridazole insoluble powder (Romvac Bucharest), mixed in feed, for 5 days dose of 25mg kg.bw. During the observation, two mortalities were recorded, representing 13.33% of the treated lot. Other animals from the group were clinically cured, the signs of the disease gradually disappeared, and the temperature returned to normal enteric symptoms. The observation period after the 21 days of experiment, the batch weight was 114.2 kg, corresponding to growth registered 95.5 g/head/day.
Group II, of 15 pigs with enteritis clinical signs, have had an average weight per lot of 7.48 kg/head, and he has undergone treatment with tiamulin product (Novartis Animal Health) soluble granules, in drinking water. Treatments were performed for 5 consecutive days at a dose of 60 mg/litre of drinking water. In this group, diarrhoea symptoms decreased and general status of the animals gradually improved, no mortality was recorded five days after the treatment, no longer signs of illness being observed, all animals became normothermic. Weight gain recorded on our observation period was 29.3 kg/ lot which correspond to average daily gain of 162.7 g/day/animal.
Group III, considered as control group, was at the beginning of the observation period, established with the average weight per lot, of 7.88 kg/head. In this series evolved enteritis with clear clinical manifestations (acute and subacute forms) and during the experiment did not receive any treatment. Within this lot, in the studied period have died five piglets which represent 33.33% of the group. Consequently, to avoid the unnecessary losses, in the 21 day of experiment, the 10 remaining piglets were orally treated with tiamulin (60 mg/litre drinking water). Subsequent observations have shown gradual improvement and clinical remission to the remaining piglets. In the control group, practically can’t talk about a weight gain. After the 21 day average daily gain for animals remaining batch was 45.1 g/day/animal.
Experiment II
The groups were selected from age group 35-45 days, which are each, composed of 12 heads per group.    Group I was treated with soluble granules tiamulin concentration of 45 mg of active substance per litre of drinking water. Treatment was performed over a period of 5 days. During the experiment, within this group there was one death case representing 8.33%. The remaining 12 piglets were cured within two weeks. Initial weight was of 92.9 kg / group, and after 21 days of experiment, it reached at 98.9 kg, corresponding to an average daily gain of 101.5 g/head/day. Although, there was loss of a pig, average daily gain of piglets remaining was considered positive, the group recorded an increase of 6 kg in the 21 days of study.
Group II received in drinking water, soluble tiamulin at concentration of 60 mg / litre for 5 consecutive days. In this group there was no mortality, all 12 piglets to heal within 10 days (cure rate 100%). The final weight for this group was of 117.6 kg (a plus of 24.9 kg), the recorded growth being of 172.8 g/head/day.
Group III was treated the injectable product Tiamutin 200 (1ml / 20kg.bw. intramuscularly for 4 days. Registered losses were 2 pigs, the remaining 10 piglets healing within 10 to 14 days. If this group, because of the recorded mortality (average daily gain 79.1 g/head/day), have not economic efficiency.
Group IV – control has not received any treatment within 7 days of the experiment.
During this time four piglets died (all with forms of hemorrhagic enteritis) and accounted for a proportion of 33.3% of the lot. After those seven days, in the aim to reduce the unnecessary losses, the remaining piglets were treated with tiamulin soluble dose to 90 mg / l for 5 consecutive days. Note that all the remaining 8 animals treated were cured. The economic indicators showed clearly the weight declining. At the end of the experiment, there was a loss of 26 kg and four dead piglets. In conclusion, the comparative use in therapy of tiamulin and dimetridazole, preparations having effect in swine’s dysentery, have shown that, both have certain therapeutic effects, but tiamulin far proved to be most effective. The results come to confirm other studies showing superior efficacy of tiamulins as preventive and curative choice in swine dysentery with Brachyspira hyodysenteriae.

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The efficacy of fenbendazole on horse strongyle infestation from Bazosul nou, Timis County

Authors: Morariu S.1, Dărăbus Gh.1, Oprescu I.1, N Mederle1, Ilie M.1, Milutin C.1, F. Morariu2,                               Stepanescu D.3

Affiliations: 1) USAMVB, Facultatea de Medicinã Veterinara Timisoara,                                                                             2) USAMVB, Facultatea de Zootehnie si Biotehnologii,                                                                                    3) Directia Sanitarã Veterinarã si pentru Siguranta Alimentelor Caras-Severin

In the last few years horse strongyles became very important because they are harmful and prejudicial for horses and horse owners. The large number of strongyle species and the possibility of apparition of benzimidazole compounds resistance phenomenon were on the basis of this study. After administration of 10% fenbendazole (Panacur) to randomic selected horses from Bazosul Nou, the efficacy of the anthelmintic by classical method FECRT and supplementary, by Borgsteede and Presidente relations, was calculated. The anthelmintic efficacy was over 99% by the mean of all three methods. The feces examination from treated horses revealed the presence of 19 species of strongyles.

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